Mr Cameron told pro-EU campaigners: "Can we be so sure peace and stability on our continent are assured beyond any shadow of doubt? Is that a risk worth taking? "I would never be so rash to make that assumption."
He referred to Britain’s role in “pivotal moments in European history: Blenheim, Trafalgar, Waterloo, our country’s heroism in the Great War and, most of all, our lone stand in 1940”.
He added: "What happens in our neighbourhood matters to Britain. That was true in 1914, 1940, 1989.... and it is true in 2016."